Required fields
- Clinical vignette
- Pathology image or image set
- Question stem
- Multiple-choice answers
- Correct answer
- Explanation
- Key visual clue
- Why the other answers are incorrect
- Difficulty level
- Linked pattern-library topic
- Educational objective
Sample item
Clinical Vignette
A 42-year-old patient presents with nephrotic-range proteinuria and edema. A PAS-stained kidney biopsy image is shown.
Question
Which visual feature best supports the most likely pattern?
Answer choices
- A. Segmental collapse of capillary loops
- B. Nodular mesangial expansion
- C. Cellular crescent formation
- D. Diffuse interstitial eosinophilic infiltrate
- E. Arteriolar onion-skinning
Correct Answer
B. Nodular mesangial expansion
Explanation
The image demonstrates nodular mesangial expansion, a classic visual pattern associated with diabetic kidney disease in the appropriate clinical context.
Key Visual Clue
Round, PAS-positive mesangial nodules within glomeruli.
Educational Objective
Recognize nodular mesangial expansion and connect the visual pattern to the clinical differential diagnosis.
For educational use only. Not intended for clinical diagnosis or patient care decisions.